ABSTRACTAutophagy is a survival mechanism by which cells adapt to the changes of the microenvironment. It may play two completely opposite roles in promoting or inhibiting the progression of cancer, depending on specific cellular conditions, including ROS levels, metabolic stress status, and other microenvironmental factors. However, the mechanism underlying autophagy regulation of cancer development ...

目的:课程以临床康复"一体化"为核心,采用多要素联合教学模式评估临床专业实习教学实施中的效果.在骨与运动创伤等疾病的带教指导等教学环节融入"一体化"概念,探讨增强多要素联合教学模式在增强临床康复"一体化"教学中的改革效果.方法:选取临床医学本科在浙江大学医学院附属第一医院骨科实习生共52名,随机分为教改组和对照组,教改组共26人使用传统授课教学模式(Lecture Based Learning,LBL)、案例为基础的教学(Case Based Learning,CBL)...

AbstractBackground: The percentage of microcytic cells (%MICRO) and the percentage of hypochromic cells (%HYPO) were very useful in differentiating microcytic anemia, and hematological parameters had significant potential as predictive markers of the degree of α-gene deletions. This study aims to evaluate the value of these research parameters in screening for α-thalassemia compared to classical ...

AbstractThis study aims to investigate the association between visit-to-visit blood pressure variability (VVV) in early stage of continuous ambulatory peritoneal dialysis (CAPD) and long-term clinical outcomes, utilizing machine learning algorithms.Patients who initiated CAPD therapy between January 1, 2006, and December 31, 2009 were enrolled. VVV parameters were collected during the first six months ...

Early diagnosis of breast cancer is critical for improving prognosis, but traditional methods have limitations.Herein, we propose an SPC-CRISPR system for the sensitive and specific detection of multiple breast cancer exosomal proteins without prior exosome isolation. This system couples CRISPR system with an enzyme-free amplification method to achieve dual-signal amplification. SPC-CRISPR is based ...

AbstractBackground: PTEN loss has been identified in various tumor types and is linked to unfavorable clinical outcomes. In addition to PTEN mutation, multiple mechanisms contribute to PTEN loss during tumor development. However, the natural selection process of PTEN-deficient tumor cells remains unclear. Here, we aimed at further elucidating the role of PTEN-L in tumor progression.Methods: PTEN knockout ...

随着互联网技术和计算机技术的快速发展，仿真和虚拟现实技术在国内各大领域中得到了广泛关注和应用。在医学检验领域中，仿真和虚拟现实技术也以虚拟实验室的形式应用于教学。本文对虚拟仿真实验在检验医学实验教学中的意义、应用现状进行论述，分析了虚拟仿真实验应用于实验教学的优势，提出了医学检验实验教学未来可能发展方向的思考与见解，并对仿真虚拟实验的发展应用提出新的展望。

临床分子生物学检验技术已广泛应用于遗传性疾病的诊断和预防、感染性疾病的诊断和监测、肿瘤等范围。因此，临床分子生物学检验技术这门课程是医学检验专业的核心课程之一，我国大部分医学本科院校把改课程作为医学检验技术专业必修课，设置理论和实验课相结合的教学模式。实验教学是顺利实现由理论向临床过渡的关键课程，但由于大多数分子实验所需的仪器设备较为昂贵，国内一般高校都难以配备足够的实验设施，因此许多分子实验无法开展，...

探讨在临床微生物学检验技术课程中如何以学生为中心融入课程思政的探索与实践。首先，分析传统教学模式下临床微生物学检验技术课程教学存在的痛点问题。接着，根据学生能力培养需求和临床发展需求，践行以学生为中心的教学模式，运用问题导学法、情景教学法、案例教学法、实践教学法等经典的教学方法，把思政元素揉进课程教学。最后，通过改革课程评价体系，量化课程评价指标，增加课程思政建设考核比重等举措检验课程思政建设成效。...

医学检验专业作为一门实践性强的应用学科，注重科研创新能力和综合实践能力的锻炼。项目式教学是实践教学体系的深度改革，该研究通过项目式实践教学内容的确定、实施方法与过程、灵活开展方式几方面介绍项目式实践教学的构建过程。实践证明，该教学方式可有效调动学生积极性，对学生专业素质和职业能力的培养具有推动作用。