AbstractExtracellular vesicles (EVs) can facilitate essential communication among cells in a range of pathophysiological conditions including cancer metastasis and progression, immune regulation, and neuronal communication. EVs are membrane-enclosed vesicles generated through endocytic origin and contain many cellular components, including proteins, lipids, nucleic acids, and metabolites. Over the ...

利用自然堆肥、表面活性剂强化堆肥和复合菌群强化堆肥三种方式进行了石油污染土壤的堆肥修复，比较堆肥效果，利用16s rDNA高通量测序分析了堆肥过程微生物群落结构变化，探讨了不同堆肥方式中烃降解规律与菌群组成的关系。结果表明：两种强化堆肥均能有效降解土壤中石油烃，其中添加了鼠李糖脂的堆体烃降解率可达88%。不同堆肥方式烃降解规律的不同是由优势烃降解菌群的不同导致的，自然堆肥中Rhodococcus sp.作为主要的烃降解功能微生物发挥主要作用；...

Background: Severe community-acquired pneumonia (sCAP) is a condition where infection-induced lung tissue inflammation intensifies to a certain stage, resulting in organ dysfunction and even life-threatening disease. When sCAP occurs, neutrophils and monocytes will be activated and released into the peripheral blood to kill bacteria. There are significant morphological changes in these activated neutrophils ...

Background: Icariin presents protective effect in several kidney diseases. However, the role of icariin in contrast-induced acute kidney injury (CIAK) is still unclear. This study aimed to investigate the effect of icarin in CIAKI, as well as exploring the underlying mechanism from the aspect of interaction between protein-coding genes and non-coding RNAs.Methods: The effect of icarin was evaluated ...

Abstract. Breast cancer is one of the most common malignant tumors in women. Cell division cycle-associated 5 (CDCAS) is closely associated with the behavior of various cancer types.The aim of the present study was to explore the effect of CDCAS on breast cancer. Western blot analysis and reverse transcrip-tion-quantitative PCR were used to detect the expression level of CDCAS in human normal mammary ...

ABSTRACTIPurpose: Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus(T2DM), but its effective prevention and treatment are still limited. We investigated the effects of GYY4137, a slow-releasing hydrogen sulfide donor, and its downstream mediator forkhead box protein 01 (FOX01) on T2DM-associated DCM. Methods: In vivo, T2DM mice were induced by a high-fat diet coupled ...