信号放大技术的快速发展为比率型电化学生物传感器的设计提供了新思路。首先，综述了近5年来多种信号放大技术在比率型电化学生物传感器领域的应用进展；然后，系统介绍了3种不同类型的信号放大应用手段；最后，展望了其在比率型电化学生物传感器的应用前景。

摘要：临床分子生物学检验技术是医学检验专业的核心课程之一，我国大部分高职高专医学院校把临床分子生物学检验技术作为医学检验技术专业必修课。临床分子生物学检验技术是以分子生物学的原理和技术为基础，通过检测生物样本中 DNA、RNA、蛋白质等生物大分子的量变或质变，从而为疾病的预防、珍断、治疗、预后提供生物信息和诊疗依据的应用学科。临床分子生物学检验技术广泛应用于感染性疾病的诊断和监测、遗传性疾病的诊断和预防、...

Abstractβ-Thalassemia (β-thal) is one of the most common monogenic recessive inherited diseases worldwide. The mutation spectrum of β-thal has been increasingly broadened by various genetic testing methods. The discovery and identification of novel and rare pathogenic thalassemia variants enable better disease prevention, especially in high prevalence regions. In this study, a Chinese thalassemia ...

民办高校在推进应用型、创新型人才培养的进程中，师资队伍建设是核心和着力点。建立一支既具备深厚的专业理论知识，又有丰富的生产实践经验和创新意识的“双师型”师资队伍，是提高民办高校竞争力的重要保障。该文深入分析了民办高校“双师型”教师队伍建设存在的问题，并从调整师资准入标准、拓宽教师培养渠道、建立教师考评机制、提供政策保障、完善校企合作协同机制几个方面，探讨民办高校“双师型”教师队伍培养路径，以期为同类高校师资队伍建设工作提供一些借鉴和参考。...

目的研究熊果酸（Ursoic acid,UA）对过氧化氢（H2O2）诱导的H9C2大鼠心肌细胞氧化应激损伤的保护作用及对细胞自噬的调节作用。方法以200μmol·L-1H2O2诱导24 h建立H9C2心肌细胞氧化应激损伤模型。将H9C2细胞随机分为6组:正常组、溶剂组、模型组及熊果酸高、中、低剂量(10、5、2.5μmol·L-1)组。采用CCK-8法检测细胞存活率;EdU法检测细胞增殖能力;TBA法检测丙二醛（MDA）脂质氧化水平;WST-8法检测超氧化物歧化酶（SOD）活性;Western ...

为适应应用型人才培养的需要,提高学生解决分析实际问题的能力,采用模块化教学对医学检验技术专业分析化学课程建设进行了探索和实践。在明确分析化学的教学要求和教学目标基础上,构建了模块化分析化学教学内容体系。以应用为导向,学生为主体,采用"教、学、做、用、创"五位一体教学法提高学生解决实际问题的能力,运用信息化手段,开展多元教学模式,尝试了分析化学模块化教学新方法。探索了分析化学模块化教学考核评价新方法,分析化学教学质量得到了提升。...

ABSTRACT: Neural stem cell (NSC) differentiation and proliferation are important biological processes in the cerebral neural network. However, these two abilities of NSCs are limited. Thus, the induction of differentiation and/or proliferation through the administration of plant-derived small-molecule compounds could be used to repair damaged neural networks. The present study reported that gallic ...

AbstractBackground: Diabetic nephropathy (DN) is one of the primary causes of end-stage renal disease, yet effective therapeutic targets remain elusive. This study aims to identify novel diagnostic biomarkers and potential therapeutic candidates for DN.Methods: Differentially expressed genes (DEGs) in GSE96804 and GSE142025 were identified and functional enrichment analysis was performed. Diagnostic ...

COVID-19 belongs to a vast group of viruses rapidly disseminating worldwide. The substantial surge in infected individuals has resulted in a strain on medical facilities across the globe. Consequently, precise predictions of case numbers and fatalities can assist governments and various organizations in preplanning response strategies, alleviating the burden on the healthcare system. Deep learning ...

This study explored the mechanism of baicalein on rectal cancer. Human rectal adenocarcinoma cells HR8348 were exposed to low, moderate and high concentration of baicalein (5, 10, and 20 μmol/L), respectively, for 48 h with untreated control group, followed by analysis of glucose consumption, lactic acid and denosine triphosphate (ATP) content, cell proliferation and expression of phosphatidylinositol-...